Author's response to reviews Title:Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD Authors:

Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD

BACKGROUND Genetic factors play a role in the development and severity of chronic obstructive pulmonary disease (COPD). The pathogenesis of COPD is a multifactorial process including an inflammatory cell profile. Recent studies revealed that single nucleotide polymorphisms (SNPs) within ADAM33 increased the susceptibility to COPD through changing the airway inflammatory process and lung functio...

Author's response to reviews Title: Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population Authors:

CHRONIC OBSTRUCTIVE PULMONARY DISEASE A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology

Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality. It is associated with airway obstruction, increased airway hyper-responsiveness (AHR), and ongoing airway and lung inflammation dominated by CD8 lymphocytes and neutrophils. Singlenucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have b...

A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with increasing prevalence and mortality. It is associated with airway obstruction, increased airway hyper-responsiveness (AHR), and ongoing airway and lung inflammation dominated by CD8 lymphocytes and neutrophils. Single-nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) gene have b...

The Relationship between the Severity of Airway Obstruction and COPD Diagnostic Questionnaire Score in COPD Patients

Background & objectives: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and systemic inflammation which is also associated with pulmonary and extra-pulmonary complications. COPD Diagnostic Questionnaire (CDQ) is a valid questionnaire that is used to identify patients with COPD. The purpose of this study was to determine the relationship between ...